anginosus )
375 g every 6 h b: Ticarcillin-clavulanic acid: Intra-abdominal infection is the second most common cause of infectious mortality in the intensive care unit
Continued evidence of infection, e
Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high
Alternatively, carbapenems Carbapenems Carbapenems include Ertapenem Imipenem Meropenem Carbapenems are parenteral bactericidal beta-lactam antibiotics that have an extremely broad spectrum
The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy
Duration of antimicrobial treatment for complicated intra-abdominal infections after definitive source control: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma The short duration ranged from 1 dose to ≤10 days, with an average of 4 days, and the long duration Guidelines have been developed for selection of antibiotic therapy for intra-abdominal infections and are presented as a statement of the Surgical Infection Society endorsed by the Executive Council
Background Which antimicrobial agents provide the optimal efficacy, safety, and tolerability for the empirical treatment of complicated intra-abdominal infection (cIAI) remains unclear but is paramount in the context of evolving antimicrobial resistance
A maximum of 4 g should not be exceeded during a 24-hour period
Each single-dose vial of lyophilized FLAGYL I
ABSTRACT: Intra-abdominal infection is a broad term that encompasses a number of infectious processes, including peritonitis, diverticulitis, cholecystitis, cholangitis, and pancreatitis
Treatment of intra-abdominal infections (including peritonitis, intra-abdominal abscess, If a single 2-g dose of metronidazole is indicated in the mother, AAP states that breast-feeding should be interrupted for 12-24 hours following the dose
This prospective, randomized, open, international, multicenter study of adults with complicated intra-abdominal infections (cIAI) compared the efficacy and safety of sequential intravenous (i
Solomkin, Joseph S
Oral metronidazole 10 mg/kg/dose (to a maximum of 400 mg) given twice daily
1
Issue 1 - Definitions
Low-risk community-acquired intra-abdominal infections are those that are of mild to moderate severity (including perforated appendix or appendiceal abscess) in the absence of risk factors for antibiotic resistance or treatment failure
5 to 40 mg/kg/day IV in 3 or 4 divided doses
Percutaneously drained intra-abdominal infections do not require longer duration of antimicrobial therapy
It is the second most commonly identified cause of severe sepsis in the intensive care unit (ICU)
coli, Klebsiella species, and Bacteroides species including B
It can be given orally (by mouth) or intravaginally (inserted into the vagina)
x1 dose + Doxycycline 200 mg PO x1, then 100 mg PO q12h + Metronidazole 500 mg PO q8h
33 The antibiotic dose should be optimized to ensure that PK-PD targets are achieved
c The 95% confidence interval (CI) was calculated as an unstratified Wilson Score CI
Newer drugs: eravacycline, a novel fluorocycline antibiotic, has been evaluated against complicated mixed aerobic/anaerobic intra-abdominal infections
peritoneal cavity, mesentery, retroperitoneum) and cause localized peritonitis or diffuse peritonitis [1, 2]
1 Dosage for Adults 2
The dosage of Flagyl prescribed will depend on the specific condition being treated and the patient's individual needs
& Consider addition of Vancomycin IV for empiric Enterococcal coverage in the presence of at least one of the
Cefepime 50 mg/kg/dose IV q8h (max: 2 g/dose) + Metronidazole 30 mg/kg/dose IV q24h (max: 1
Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide
In the treatment of most serious anaerobic infections, intravenous metronidazole is usually administered initially
It is used to treat intestinal amebiases, liver amebiasis, bacterial septicemia, bone and joint infections, meningitis, brain abscess, endocarditis, endometritis, bacterial vaginosis, intra-abdominal
1016/0732-8893 (95)00079-p
Risk factors — Candida species frequently contribute to polymicrobial infections that occur following surgery on the gastrointestinal (GI) tract; upper GI tract surgery is more likely to lead to intra-abdominal candidiasis than lower GI tract surgery [ 1,2 ]
Chlamydia trachomatis and Neisseria gonorrhoeae are common Postmenstrual age 35 to 40 weeks: 7
Alternatively, carbapenems Carbapenems Carbapenems include Ertapenem Imipenem Meropenem Carbapenems are parenteral bactericidal beta-lactam antibiotics that have an extremely broad spectrum
This involves prescribing an adequate dose, according to the most This prospective, randomized, open, international, multicenter study of adults with complicated intra-abdominal infections (cIAI) compared the efficacy and safety of sequential intravenous (i
FLAGYL (metronidazole hydrochloride) For Injection, Sterile 500 mg is a parenteral dosage form of the synthetic nitroimidazole antibacterial agent 2-methyl-5-nitro-1H imidazole-1-ethanol
Compared with standard combination regimens, meropenem offers the benefits of ease of administration without the need for monitoring
In vitro data now show substantial resistance, though the FDA approved it as monotherapy for treating complicated intra-abdominal infections
fragilis, B
For over 50 years, metronidazole has been successfully used in practice, and is still considered the drug of choice, for treating many anaerobic infections
Avoid or Use Alternate Drug
The dosage of Flagyl prescribed will depend on the specific condition being treated and the patient's individual needs
Nausea, vomiting, headache, seizures, syncope, other central nervous system effects, and peripheral neuropathy can occur; rash, fever, and reversible neutropenia have been Flagyl®
5 g once a day, for treatment of adults with complicated intra-abdominal infection were compared with those of IV ceftriaxone 2 g once a day plus IV metronidazole 500 mg every 8 h
ovatus strains that had