It is
Clinical studies in humans showed that fruit juices reduced the oral bioavailability of fexofenadine by preferentially inhibiting OATP over P-gp
The aim of this work was to probe cubosomes for enhanced intestinal absorption and oral bioavailability of poorly absorbable fexofenadine HCl (FEX-HCl)
This is a single-center, randomized, double-blind, 3-period crossover trial
Regarding the molecular mechanisms for reduced exposure of fexofenadine after oral administration, it is well known that the intestinal absorption of fexofenadine
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a
Participants will be randomized to receive a Control capsule (fexofenadine single agent) under Treatment Arm 1 or a Test 1 capsule (fexofenadine and 3 mg SLS) under
Materials and methods: Two cubosomal systems were fabricated utilizing glyceryl mono-oleate, a lyotropic mono lamellar lipid as oil phase and poloxamer407 as stabilizer
This medicine is available only with your doctor's prescription
Fexofenadine was selected as a model drug that is a substrate of P -glycoprotein ( P -gp) and organic anion transporting polypeptide 1A2 (OATP1A2)
database that were either considered for, or entered into, Phase II clinical trials
allows for once or twice daily dosing, and its rapid absorption allows for an onset of action within 1-3 hours
It is suggested that in rats fruit juices may also preferentially inhibit OATP rather than P-gp-mediated transport in fexofenadine oral absorption, albeit to a lesser extent than observed in humans
In rats, fexofenadine was excreted unchanged in the urine, bile, and gastrointestinal tract, indicating minimal metabolism, making it an ideal probe to study 1
Based on this theory, the biopharmaceutical classification system (BCS) was
Tell your doctor if your condition does not improve or if it Herbal drugs are widely used for the auxiliary treatment of diseases
The absorption of oral verapamil, diltiazem and tacrolimus was not influenced by elacridar pre-treatment, and the increase in the AUC0–t of fexofenadine was approximately 3-fold when co In vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, which led to fexofenadine exposures that were approximately 3 and 5 times the exposure at the maximum recommended daily oral dose of fexofenadine hydrochloride in adults [180
In contrast, the bioavailability of desloratadine was unaffected by juice (fruit) decreases levels of fexofenadine by inhibition of GI absorption
letermovir increases levels of fexofenadine by Other (see comment)
In rats, fexofenadine was excreted unchanged in the urine, bile, and gastrointestinal tract, indicating minimal metabolism, making it an ideal probe to study The objective of this study was to investigate the effects of fruit juices on the oral absorption of fexofenadine in rats to establish a preclinical fruit juice–drug interaction model