The plasma half-life of labetalol following oral administration is about 6 to 8 hours
With 50% protein binding, 5% renal excretion and a moderate half-life, labetalol presents moderately low risk for accumulation in infants
The plasma half-life of labetalol following oral administration is about 6 to 8 hours
Pharmacokinetics and Metabolism
Steady-state plasma levels of labetalol during repetitive dosing are reached by
In patients with decreased hepatic or renal function, the elimination half-life of labetalol is not altered; however, the relative bioavailability in hepatically impaired patients is increased due to decreased "first-pass" metabolism
In patients with decreased hepatic or renal function, the elimination half-life of labetalol is not altered; however, the relative bioavailability If overdosage with labetalol HCl follows oral ingestion, gastric lavage or pharmacologically induced emesis (using syrup of ipecac) may be useful for removal of the drug shortly after ingestion
5 mcg/L after maternal doses ranging from 330 to 400 mg daily
8 h; even while quite different, they are both short implicating that dosing three times daily is optimal
The plasma half-life of labetalol following oral administration is about 6 to 8 hours
5 hours and the total body clearance is approximately 33 mL/min per kilogram
It is moderately lipid soluble and is completely absorbed after oral administration
ORAL: Initial dose: 100 mg orally 2 times a day (alone or added to a diuretic regimen) Titration: Dosage may be increased in increments of 100 mg orally 2 times a day every 2 or 3 days
There is no significant evidence of exposure or accumulation in breastfed infants
Certain beta-blockers, such as propranolol, with a half-life of approximately 4 hours, are dosed up to 3 or 4 times a day, depending on the indication
Tell all health professionals that you take labetalol as it may interfere with some procedures
Peak concentrations are reached within 5 minutes of labetalol injection
Since the half-life of labetalol is 5 to 8 hours, steady-state blood levels (in the face of a constant rate of infusion) would not be reached during the usual infusion time period
Half-Life Elimination
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body