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Recent investigations utilizing large cohorts of gout patients who Colchicine (COL) is a classical antimitotic, tubulin-binding agent (TBA) which is being explored as anticancer drug
It is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies
The dynamic state of anticancer drug development from colchicine semisynthetics and natural colchiine production is reviewed and col chicine biosynthesis is briefly
Mitotic inhibitor The structure of paclitaxel, a widely used mitotic inhibitor
The Colcrys brand of colchicine is FDA-approved to treat or prevent gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who
Similar to combretastatin and colchicine, methoxylated chalcones bind to tubulin and prevent its polymerization, Recent Pat
Food and
This review focuses on the anticancer role of some of colchicine-based derivatives and their therapeutic importance
Cases of myopathy and/or rhabdomyolysis in patients receiving colchicine have Colchicine (1), a nature-derived microtubule polymerization inhibitor, develops multi-drug resistance in tumor cells due to its P-gp substrate and induction activity, which in turn leads to its rapid efflux from tumor cells
In contrast to the findings concerning antifungal potency, the anticancer studies showed complexes of colchicine more active (~IC 50 = 2 nM) than those of colchiceine (~IC 50 = 6 μM)
Here, we have shown that Effect of various nutritional components and fermentation parameters on biotransformation of colchicine using Bacillus megaterium ACBT03 to produce 3-demethylated colchicine (3-DMC) has been investigated
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer
Colchicine, known as an agent used to ameliorate acute gout attacks because of its microtubule disruption activities, has been studied for its possible anticancer effects 67
Similar to combretastatin and colchicine, methoxylated chalcones bind to tubulin and prevent its polymerization, Recent Pat
Despite having remarkable anticancer potential, colchicine could not pave its way to the clinic, while gloriosine is yet to be investigated for its pharmacological effects
This article reviews the dynamic state of anticancer drug development from colchicine semisynthetics and natural colchicine production and briefly discusses colchicine Colchicine has been used for the treatment and prevention of gouty arthritis and has been reported to have an anticancer effect in vitro
Each new year the FDA approves the use of new drugs for cancer treatments
Colchicine's value as an anticancer drug is undercut by harmful side effects, but a related compound may offer a useful alternative
1 These crystals interact with macrophages Colchicine (COL) is a classical antimitotic, tubulin-binding agent (TBA) which is being explored as anticancer drug