Hydroxychloroquine, sold under the brand name Plaquenil (Sanofi-Aventis), is an antimalarial drug that has gained widespread use
PATIENTS AND METHODS Six patients being treated for various
Multifocal ERG ring ratios provide a sen-sitive and objective method to detect ocular toxicity in patients taking hydroxychloroquine (Plaquenil)
Abstract
Hydroxychloroquine (Plaquenil) and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina
Despite the advent of newer drugs, hydroxychloroquine (HCQ) continues to be a mainstay in the treatment of systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), and
Signs
Screening for hydroxychloroquine-induced retinal toxicity presents a challenge to the screening ophthalmologist, and even to the retina specialist
The SAP (24-2 Common Plaquenil side effects may include: headache, dizziness; nausea, vomiting, stomach pain; loss of appetite, weight loss; feeling nervous or irritable; skin rash or itching; or
Aetna considers the following medically necessary: Electroretinogram or electroretinography (ER G) as an adjunctive modality in establishing loss of retinal function and distinguishing retinal from optic nerve lesions; Multi-focal ERG (mfERG) for detecting chloroquine (Aralen) and hydroxychloroquine (Plaquenil) toxicity; A Plaquenil screening may include a visual field test, OCT imaging, multifocal ERG, and photos of your eye
Signs
Lupus, el cual causa fiebre, erupciones cutáneas, problemas de la piel, y otrossíntomas
The ERG to a red flash under dark-adapted conditions is particularly useful to identify selective rod dysfunction in these patients and can be used to verify the cone system origin of residual The ERG is an objective examination, which needs almost no participation from the patient
The summed electrical response is a The flicker ERG was overall stable may have higher sensitivity than perimetry [24, 28, [33][34][35][36][37] and are part of the standard Plaquenil patient workup
The drug can temporarily be stored at temperatures between 59°F and 86°F (15°C and 30°C), such as when traveling
“Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so Patients starting chloroquine (CQ) or hydroxychloroquine (HCQ; i
Figure 1 is an image of an ocular fundus using autofluorescence to designate an area of retinal damage
Nebbioso MGrenga RKaravitis P Early detection of macular changes with multifocal ERG in patients on antimalarial drug therapy