Effect of antibiotic stewardship on the incidence of
Effect of BPA exposure on placental weight, fetal weight, placental apoptosis, OS and mitochondrial dysfunction of pregnant ewes
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While mitochondria's importance is acknowledged in all cell types, research has revealed the exceptionally dynamic nature of the mitochondrial network in oocytes and embryos
Exposing mice to these risk factors resulted in conditions resembling pre-IBD and impaired mitochondrial bioenergetics in the colonic epithelium, which triggered dysbiosis
We hypothesized that antibiotics cause mammalian mitochondrial damage while causing bacterial lethality
Therefore, our longevity study reveals To enhance accumulation of antibiotics within the mitochondria of cancer cells, and therefore delivery of a greater potency payload, a mitochondrial targeting group in the form of a triphenylphosphonium (TPP) cation was appended via an alkyl chain length consisting of 7 to 11 carbons to the ribosomal antibiotics azithromycin and doxycycline At first sight, the use of antibiotics to treat mitochondrial diseases seems paradoxical and controversial because, as previously exposed, they may interfere with mitochondrial function
Clinical usage of several classes of antibiotics is associated with moderate to severe side effects due to the promotion of mitochondrial dysfunction
Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to
Commonly-used antibiotics in the tetracycline class have been shown to impair cellular respiration and mitochondrial function in eukaryotic cells, from plants to mice to fruit flies, and in human
The effects on mitochondria are also noted with other macrolides antibiotics: josamycin reduces mitochondrial respiration and up-regulates glycolysis genes with an increment of ATP production attributable to glycolysis (Gupta et al
They originate from a bacterial ancestor and maintain their own Interestingly, several classes of FDA-approved antibiotics inhibit mitochondrial biogenesis as a known "side-effect", which could be harnessed instead as a "therapeutic effect"
Mitochondria / drug effects*
According to the endosymbiont theory, mitochondrion is of Alcohol, antibiotics, metals, bisphenols, phthalates, pesticides and herbicides, and statins—the list is long—all impair mitochondrial function
Such compounds include the antibiotics doxycycline and azithromycin, diphenyleneiodonium chloride (DPI) (a metabolic inhibitor), and vitamin C
They're responsible for capturing light energy to make sugars in photosynthesis