Significant macrocytosis is usually defined as an MCV greater than 99
9% via the syringe pump at same rate as the Phenytoin (set volume limit at 2 mL)
Macrocytic anemias are generally
Causes of macrocytosis include alcohol intake, vitamin B12 and folate deficiency, chemotherapy and other drugs, hemolysis or bleeding, liver dysfunction
Up to 70% of patients on oral zidovudine will develop macrocytosis after 2 weeks of therapy
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels
g
Macrocytosis is reported in terms of mean corpuscular volume (MCV)
No patient exhibited anemia or macrocytosis suggestive of cellular folate deficiency either during or following pregnancy
Macrocytic anemia is a condition in which red blood cells are too large
While macrocytosis and Macrocytosis in adults is defined as a red blood cell (RBC) mean corpuscular volume (MCV) >100 femtoliter (fL)
Preparations containing phenytoin sodium are not bioequivalent to those containing phenytoin base (such as Epanutin Infatabs® and Epanutin® suspension); 100 mg of phenytoin sodium is approximately equivalent in therapeutic effect to 92 mg phenytoin base
3 (cap)
In 2000, the FDA approved the use of the oral formulation as adjunctive therapy for the treatment of focal seizures, myoclonic seizures, and primary generalized seizures
However, there are data to suggest nonanemic folate deficiency may be detrimental to the patient
While macrocytosis and megaloblastic anemia have occurred, these conditions usually
This activity describes the indications, mechanism of action, and contraindications for folic acid as a valuable agent in
We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron
While macrocytosis and megaloblastic anemia have occurred, these conditions usually
Phenytoin Sodium Milpharm 100 mg film-coated tablets contain Sodium: Phenytoin sodium contains less than 1 mmol (23 mg) of sodium per
Lymphadenopathy Phenytoin Sodium Injection can be given diluted with normal saline
Pancytopenia can be associated with a multitude of disease states, some of which are life threatening