4%, Mechanism of action HH location Key results/findings; Glycopyrronium tosylate (GT) Topical oxybutynin gel is currently approved for the treatment of an overactive bladder in adults Oxybutynin, an anticholinergic medication, is approved by the U
It is generally used to relieve urinary and bladder difficulties, including frequent urination and the inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder [ 16 ]
It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline
Oxybutynin is an oral drug that is used for treating urinary bladder spasm
2
OAB is defined as the presence of urinary urgency, usually accompanied by daytime urinary frequency and nocturia, with or without urgency urinary incontinence, in the
Five subtypes (M1–M5) have been characterized, and more than one may be present in a particular organ [Caulfield and Birdsall, 1998]
Hyperhidrosis (excessive sweating) is a chronic autonomic disorder that can be debilitating leading to emotional and social embarrassment, as well as occupational, physical and psychological disability []
Oxybutynin
Oxybutynin (Ditropan, Ditropan XL, Oxytrol) is an overactive bladder medication that comes in many formulations — an immediate-release tablet, extended-release tablet, skin patch, and more
Muscarinic M 3 receptors are primarily responsible for detrusor contraction
Oxybutynin has moderate selectivity for the M3 relative to the M 2 An EEG was performed after a single dose of oxybutynin, tolterodine, trospium or placebo, and outcomes demonstrated that a single dose of oxybutynin significantly reduced (P < 0