Gemfibrozil significantly increased plasma HDL cholesterol, apolipoprotein (apo) AI, and apo AII by 36%, 29%, and 38% from
In this study, we demonstrated that high glucose promoted ferroptosis of astrocytes by disrupting iron metabolism and suppressing the xCT/GPX4-regulated pathway in diabetic mice and astrocytes cultured in high glucose
3), suggesting that gemfibrozil may not couple to posttranscriptional pathways required for the regulation of iNOS expression and that gemfibrozil inhibits the expression of
Less than 6% of
Although coadministration with gemfibrozil and fenofibrate increased the bioavailability of ezetimibe, the clinical significance is thought to be minor
Diabetes Care
Fibrates are a class of drugs utilized in the management and treatment of dyslipidemia
repaglinide and rosiglitazone [5, 25]
Gemfibrozil is a lipid-modifying agent that belongs to the fibric acid derivative class
59,60 Gemfibrozil had only a modest effect when administered with pitavastatin in 24 subjects with an increase of 45% in the AUC
Administration of gemfibrozil, a known PPARα agonist, inhibited ferroptosis and
Methods: Repaglinide metabolism was assessed in vitro (human liver subcellular fractions, fresh human hepatocytes, and recombinant enzymes) and the resulting incubates