For hypertension: Doses >75 mg/day may not provide additional reductions in blood pressure Next: Interactions Enter a drug name and spironolactone All Interactions Sort
The maximum daily dose is up to 400mg daily
Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses
Usual Adult Dose of Aldactone for Edema: 25 to 200 mg orally per day in single or divided doses
Initial dose: 25 mg orally once a day; titrate to the target dose preferably within 4 weeks as tolerated
Adult: Initially, 100-200 mg daily, may be gradually increased up to 400 mg daily for severe cases
CrCl < 25 mL/min: Not recommended
Oral estrogen
2 25 to 200 mg/day The daily adult dose of spironolactone (Aldactone) is 25 to 200 mg/day in single or two divided doses
Maintenance dose should be individually determined
The dosage of spironolactone should remain unchanged when other diuretic therapy is added
Researchers recommend starting with a low dose and increasing the dose only if necessary to control acne symptoms
3
Studies that examine the effect of spironolactone on PCOS have shown that: Spironolactone lowered testosterone, LH, and prolactin in women with PCOS2 (at a dosage 50-75 mg per day) Spironolactone improved insulin resistance markers and triglycerides in overweight women and increased HDL (good) cholesterol in lean women
If response is not satisfactory after initial 5 days of therapy, add a thiazide or loop diuretic
It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low
Side effects are transient
The recommended initial dose is spironolactone 100-200 mg/d and furosemide 20-40 mg/d