345 Abstract Objective: To examine retrospectively the
These interactions may affect how well levothyroxine is being absorbed
Possible drug interactions with levothyroxine include: Amiodarone — serum
Sucralfate, antacids and proton pump inhibitors may cause hypochlorhydria, affect intragastric pH, and reduce levothyroxine absorption
Levothyroxine (LT4) and proton pump inhibitors (PPI) are two of the most prescribed drugs particularly in elderly population [1,2]
These drug–drug interactions have been previously reviewed
Authors Yuli Guzman-Prado 1 , Roberto Vita 2 , Ondrej Samson 3 Affiliations 1 Dorset, United Kingdom
Manufacturer advises monitor thyroid function
Switch to professional interaction data Possible drug interactions with levothyroxine include: Gastrointestinal ulcer-healing drugs — sucralfate or cimetidine and proton pump inhibitors may reduce the absorption of levothyroxine
This review aimed to investigate
You may be able to take other medications with levothyroxine, but some of them will have to be taken at a different time from when you take your levothyroxine
Synthroid (levothyroxine) Tylenol (acetaminophen) Vitamin B12 (cyanocobalamin) Vitamin C (ascorbic acid) Vitamin D2 (ergocalciferol) Vitamin D3 (cholecalciferol) Xanax (alprazolam) Zoloft (sertraline) Zyrtec (cetirizine) Omeprazole disease interactions
This large study demonstrates the significant interaction between levothyroxine and iron, calcium, proton pump inhibitors, statins and estrogens
Porphyria (enzyme problem)—Use with caution
Common interactions include pain in extremity among females, and fatigue among males
First, these shouldn’t be taken together
PPIs should be added to the list of medications affecting the level of thyroid hormone in patients with hypothyroidism treated with LT 4 replacement
Proton pump inhibitors (omeprazole, lansoprazole) Finally, some drug interactions with levothyroxine can be explained by an effect on its metabolism, such as the extrathyroidal conversion rate of T 4 to T 3